Introduction: Although epidemiological studies demonstrated that HDL cholesterol (HDL-C) levels are associated with higher cardiovascular risk, pharmacological interventions for elevated HDL-C levels have failed to show a risk reduction. Objective: To evaluate patients admitted for acute myocardial infarction (AMI) to determine whether HDL-C levels measured up to 1 year before the event have an impact on post-event mortality. Methods: A retrospective cohort study was conducted using data from the database of the Curitiba (Brazil) city hall. This study included 1,363 patients hospitalized from 2008 to 2015, with a diagnosis of infarction and available HDL-C values measured up to 1 year before the coronary event. The mean HDL-C levels obtained in this period and at 6 and 12 months after discharge were correlated with hospital mortality. Results: HDL-C levels of \u226435 mg\/dL resulted in lower mortality than values of \u226550 mg\/dL. This indicates that the mortality risk of patients with HDL-C levels of \u226550 mg\/dL was 30% higher than \u226435 mg\/dL, regardless the age and the total follow up. The survival rate at 6 and 12 months of follow-up for patients with HDL-C levels of \u226550 mg\/dL was reduced in relation to other quartiles, with higher evidence of mortality at 12 months. Conclusions: The patients with higher HDL-C levels in the year preceding an AMI presented worse prognosis than those with lower HDL-C levels after the acute event. This reinforces the paradoxical effect of HDL-C on cardiovascular risk and the results of recent intervention studies.<\/p>\n","protected":false},"excerpt":{"rendered":"

Introduction: Although epidemiological studies demonstrated that HDL cholesterol (HDL-C) levels are associated with higher cardiovascular risk, pharmacological interventions for elevated HDL-C levels have failed to show a risk reduction. Objective: To evaluate patients admitted for acute myocardial infarction (AMI) to determine whether HDL-C levels measured up to 1 year before the event have an impact on post-event mortality. Methods: A retrospective cohort study was conducted using data from the database of the Curitiba (Brazil) city hall. This study included 1,363 patients hospitalized from 2008 to 2015, with a diagnosis of infarction and available HDL-C values measured up to 1 year before the coronary event. The mean HDL-C levels obtained in this period and at 6 and 12 months after discharge were correlated with hospital mortality. Results: HDL-C levels of \u226435 mg\/dL resulted in lower mortality than values of \u226550 mg\/dL. This indicates that the mortality risk of patients with HDL-C levels of \u226550 mg\/dL was 30% higher than \u226435 mg\/dL, regardless the age and the total follow up. The survival rate at 6 and 12 months of follow-up for patients with HDL-C levels of \u226550 mg\/dL was reduced in relation to other quartiles, with higher evidence of mortality at 12 months. Conclusions: The patients with higher HDL-C levels in the year preceding an AMI presented worse prognosis than those with lower HDL-C levels after the acute event. This reinforces the paradoxical effect of HDL-C on cardiovascular risk and the results of recent intervention studies.<\/p>\n","protected":false},"author":1,"featured_media":11778,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4133,4132,4137],"tags":[4162,4165,4166,4164,4163],"acf":[],"_links":{"self":[{"href":"https:\/\/www.jcdam.net\/wp-json\/wp\/v2\/posts\/11795"}],"collection":[{"href":"https:\/\/www.jcdam.net\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.jcdam.net\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.jcdam.net\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.jcdam.net\/wp-json\/wp\/v2\/comments?post=11795"}],"version-history":[{"count":1,"href":"https:\/\/www.jcdam.net\/wp-json\/wp\/v2\/posts\/11795\/revisions"}],"predecessor-version":[{"id":11803,"href":"https:\/\/www.jcdam.net\/wp-json\/wp\/v2\/posts\/11795\/revisions\/11803"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.jcdam.net\/wp-json\/wp\/v2\/media\/11778"}],"wp:attachment":[{"href":"https:\/\/www.jcdam.net\/wp-json\/wp\/v2\/media?parent=11795"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.jcdam.net\/wp-json\/wp\/v2\/categories?post=11795"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.jcdam.net\/wp-json\/wp\/v2\/tags?post=11795"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}